Coenzyme Q10 (CoQ1) is made naturally in the body and sold as a supplement. It has many roles, including energy production and protection from oxidative cell damage. The dosage varies based on what you want to treat.
This article reviews the best dosages for CoQ10, depending on your needs.
What is CoQ10?
Coenzyme Q10, or CoQ10, is a fat-soluble antioxidant in all human cells, with the highest concentration in the mitochondria.
Mitochondria — often referred to as the powerhouses of cells — are specialized structures that produce adenosine triphosphate (ATP), the main energy source used by your cells.
There are two forms of CoQ10 in your body: ubiquinone and ubiquinol.
Ubiquinone is converted to its active form, ubiquinol, which is then readily absorbed and utilized by your body.
Aside from being naturally produced by your body, CoQ10 can be obtained through foods, including eggs, fatty fish, organ meats, nuts, and poultry.
CoQ10 plays a fundamental role in energy production and is a powerful antioxidant, inhibiting free radical generation and preventing cell damage.
Though your body makes CoQ10, several factors can deplete its levels. For example, its production rate significantly declines with age, which is associated with the onset of age-related conditions like heart disease and cognitive decline.
Other causes of CoQ10 depletion include statin medication use, heart disease, nutrient deficiencies, genetic mutations, oxidative stress, and cancer.
Supplementing with CoQ10 has been shown to counteract damage or improve conditions related to a deficiency in this important compound.
Additionally, as it’s involved in energy production, CoQ10 supplements have been shown to boost athletic performance and decrease inflammation in healthy people who are not necessarily deficient.
Summary: CoQ10 is a compound with many important functions in your body. Various factors can deplete CoQ10 levels, so supplements may be necessary.
CoQ10 dosage recommendations by health condition
Though 90–200 mg of CoQ10 per day is typically recommended, needs can vary depending on the person and condition being treated.
Statin medication use
Statins are a group of medications used to lower high blood levels of cholesterol or triglycerides to prevent heart disease.
Though these drugs are generally well tolerated, they can cause adverse side effects, such as serious muscle injury and liver damage.
Statins also interfere with the production of mevalonic acid, which is used to form CoQ10. This has been shown to decrease CoQ10 levels in the blood and muscle tissues significantly.
Research has shown that supplementing with CoQ10 reduces muscle pain in those taking statin medications.
A study of 50 people taking statin medications found that 100 mg of CoQ10 per day for 30 days effectively reduced statin-related muscle pain in 75% of patients.
However, other studies have shown no effect, emphasizing the need for more research on this topic.
The typical dosage recommendation for CoQ10 for people taking statin medications is 30–200 mg per day.
Those with heart conditions, such as heart failure and angina, may benefit from a CoQ10 supplement.
A review of 13 studies in people with heart failure found that 100 mg of CoQ10 per day for 12 weeks improved blood flow from the heart.
Plus, supplementing has been shown to reduce the number of hospital visits and the risk of dying from heart-related issues in individuals with heart failure.
CoQ10 also effectively reduces the pain associated with angina, which is chest pain caused by your heart muscle not getting enough oxygen.
Moreover, the supplement may reduce heart disease risk factors by lowering “bad” LDL cholesterol.
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For people with heart failure or angina, the typical dosage recommendation for CoQ10 is 60–300 mg daily.
When used alone or in combination with other nutrients, such as magnesium and riboflavin, CoQ10 has been shown to improve migraine symptoms.
It has also been found to ease headaches by reducing oxidative stress and free radical production, which may otherwise trigger migraines.
CoQ10 decreases inflammation in your body and improves mitochondrial function, which helps reduce migraine-associated pain.
A three-month study of 45 women demonstrated that those treated with 400 mg of CoQ10 daily experienced significant reductions in the frequency, severity, and duration of migraines compared to a placebo group.
The typical dosage recommendation for treating migraines for CoQ10 is 300–400 mg daily.
As mentioned above, CoQ10 levels naturally deplete with age.
Thankfully, supplements can raise your levels of CoQ10 and may even improve your overall quality of life.
Older adults with higher blood levels of CoQ10 tend to be more physically active and have lower levels of oxidative stress, which may help prevent heart disease and cognitive decline.
CoQ10 supplements have improved older adults’ muscle strength, vitality, and physical performance.
To counteract the age-related depletion of CoQ10, it’s recommended to take 100–200 mg daily.
Both oxidative stress and mitochondrial dysfunction have been linked to the onset and progression of diabetes and diabetes-related complications.
Moreover, those with diabetes may have lower levels of CoQ10, and certain anti-diabetic drugs may further deplete body stores of this important substance.
Studies show that supplementing with CoQ10 helps reduce the production of free radicals, which are unstable molecules that can harm your health if their numbers get too high.
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CoQ10 also helps improve insulin resistance and regulate blood sugar levels in people with diabetes.
A 12-week study of 50 people with diabetes found that those who received 100 mg of CoQ10 daily significantly reduced blood sugar, markers of oxidative stress, and insulin resistance compared to the control group.
Doses of 100–300 mg of CoQ10 daily improve diabetes symptoms.
Oxidative damage is one of the main causes of male and female infertility by negatively affecting sperm and egg quality.
For example, oxidative stress can cause damage to sperm DNA, potentially resulting in male infertility or recurrent pregnancy loss.
Research has found that dietary antioxidants — including CoQ10 — may help reduce oxidative stress and improve fertility in both men and women.
Supplementing with 200–300 mg per day of CoQ10 has been shown to improve sperm concentration, density, and motility in men with infertility.
Similarly, these supplements may improve female fertility by stimulating ovarian response and helping slow ovarian aging.
CoQ10 doses of 100–600 mg have been shown to help boost fertility.
CoQ10 is involved in energy production, so it’s a popular supplement amongst athletes and those looking to boost physical performance.
CoQ10 supplements help reduce the inflammation associated with heavy exercise and may even speed recovery.
A 6-week study in 100 German athletes found that those supplemented with 300 mg of CoQ10 daily experienced significant improvements in physical performance — measured as power output — compared to a placebo group.
CoQ10 has also reduced fatigue and increased muscle power in non-athletes.
Doses of 300 mg daily appear to be most effective in boosting athletic performance in research studies.
Summary: Dosage recommendations for CoQ10 vary depending on individual needs and goals. Speak with your doctor to determine the right dose for you.
Side effects of CoQ10
CoQ10 is generally well tolerated, even at extremely high doses of 1,000 mg daily.
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However, some people sensitive to the compound may experience side effects like diarrhea, headache, nausea, and skin rashes.
It should be noted that taking CoQ10 close to bedtime may cause insomnia in some people, so it’s best to take it in the morning or afternoon.
CoQ10 supplements can interact with common medications, including blood thinners, antidepressants, and chemotherapy drugs. Consult your doctor before taking supplemental CoQ10.
As it’s fat-soluble, those supplementing with CoQ10 should remember that it’s better absorbed when taken with a meal or snack containing a fat source.
Additionally, be sure to buy supplements that deliver CoQ10 in the form of ubiquinol, which is the most absorbable.
Summary: Though CoQ10 is generally well tolerated, some people may experience side effects like nausea, diarrhea, and headaches, especially if taking high doses. The supplement may also interact with common medications, so speak to your doctor first.
Coenzyme Q10 (CoQ10) has been linked to improved aging, exercise performance, heart health, diabetes, fertility, and migraines. It may also counteract the adverse effects of statin medications.
Typically, 90–200 mg of CoQ10 per day is recommended, though some conditions may require higher dosages of 300–600 mg.
CoQ10 is a relatively well-tolerated and safe supplement that may benefit a wide variety of people looking for a natural way to boost health.