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The best macronutrient ratio for weight loss

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A recent trend in weight loss is counting the macronutrients carbs, fats, and protein, rather than focusing on calories. This article reviews the best macronutrient ratio for weight loss and why diet quality matters.

Weight Management
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The best macronutrient ratio for weight loss
Last updated on November 18, 2023, and last reviewed by an expert on May 31, 2023.

Macronutrients are nutrients your body needs in large amounts, namely carbohydrates, fats, and proteins. Regarding weight loss, research shows that how much you eat may matter more than the amount of carbs, fat, and protein in your diet.

The best macronutrient ratio for weight loss

A recent trend in weight loss is counting macronutrients.

Your body requires large amounts of these nutrients for normal growth and development — carbs, fats, and proteins.

On the other hand, micronutrients are nutrients that your body only needs in small amounts, such as vitamins and minerals.

Counting macronutrients is similar to counting calories but differs in that it considers where the calories come from.

This article reviews the best macronutrient ratio for weight loss and why diet quality matters.

In this article

Calorie intake matters more than macronutrient ratio for fat loss

Regarding losing fat, how much you eat matters more than the amounts of carbs, fat, and protein in your food.

Researchers randomized over 600 overweight people to a low-fat or low-carb diet in a one-year study.

During the first two months of the study, the low-fat diet group consumed 20 grams of fat per day, while the low-carb group consumed 20 grams of carbs per day.

After two months, people in both groups added fats or carbs to their diet until they reached the lowest intake level they believed they could maintain.

While neither group had to consume a certain number of calories, both groups reduced their intake by an average of 500–600 calories daily.

At the end of the study, the low-fat diet group lost 11.7 pounds (5.3 kg) compared to the low-carb group, which lost 13.2 pounds (6 kg) — a mere difference of 1.5 pounds (0.7 kg) over a year.

In another study, 645 overweight people were randomly assigned to a diet that differed in proportions of fat (40% vs. 20%), carbs (35% vs. 65%), and protein (25% vs. 15%).

Regardless of the macronutrient ratio, all diets were equally successful in promoting similar amounts of weight loss over two years.

These results and others point to the fact that any reduced-calorie diet can cause similar amounts of weight loss in the long term.

How long does it take to lose weight?
Suggested read: How long does it take to lose weight?

Summary: Research shows you can lose fat regardless of your macronutrient ratio. Moreover, different macronutrient ratios do not significantly affect how much total fat you lose in the long run.

Calories don’t explain the whole story

A calorie measures the amount of energy a particular food or beverage contains. Whether from carbs, fats, or proteins, one dietary calorie contains approximately 4.2 joules of energy.

By this definition, all calories are created equal. However, this assumption fails to consider the complexities of human physiology.

Food and its macronutrient composition can influence how hungry or full you feel, your metabolic rate, brain activity, and hormonal response.

So, while 100 calories of broccoli and 100 calories of doughnuts contain the same amount of energy, they affect your body and food choices much differently.

Three cups (270 grams) of raw broccoli have close to 100 calories and pack 7 grams of fiber. Conversely, two doughnut holes provide over 100 calories from refined carbs and fats.

Now imagine eating four cups of broccoli in one sitting. It would take a lot of time and effort to chew, but its high fiber content would leave you feeling much fuller than eating two doughnut holes, in which case you will most likely want to eat more.

As a result, a calorie is not just a calorie. You should also focus on diet quality to increase dietary adherence and fat loss.

Suggested read: The top 20 biggest nutrition myths & lies

Summary: Calories supply your body with the same amount of energy. However, they differ in how they affect your health and ability to stay on track with your diet.

The importance of diet quality

To lose weight, you must create a calorie deficit by eating fewer calories than you burn.

By doing so, you force your body to draw energy from its current stores (body fat) regardless of your diet’s carb, fat, and protein makeup.

Once you create a calorie deficit, it’s important to account for the types of foods you’re eating, as some are more diet-friendly and nutritious than others.

Here are some foods and macronutrients to focus on and some to limit.

Choose nutrient-dense foods

Nutrient-dense foods contain high levels of nutrients but are relatively low in calories.

Nutrient-dense foods pack fiber, lean protein, healthy fats, vitamins, minerals, and other beneficial compounds like phytochemicals.

These include dairy, beans, legumes, whole grains, fruits, vegetables, lean meats, and fish.

Many of these foods are also fiber-rich and contain a high percentage of water. Water and fiber help increase feelings of fullness, which can help you eat fewer total calories throughout the day.

Consume high-protein foods

Protein promotes feelings of fullness, spares muscle loss, and has the highest thermic effect, meaning it takes more calories to digest than carbs or fats.

Look for lean animal-based sources like meat, fish, poultry, eggs, and dairy. You can also get protein from plant-based sources like soy, beans, lentils, and whole grains.

Protein shakes or meal-replacement beverages are also a good option between meals or in place of a meal to increase protein intake.

Limit fat and high-carb foods

Some foods can benefit your weight loss goals, but others can make them more difficult to achieve.

Suggested read: Calories in, calories out: Does it matter?

Foods that contain high amounts of fat and carbs, without much protein or fiber, can stimulate the reward center in your brain and increase your cravings, leading to overeating and weight gain.

Doughnuts, pizza, cookies, crackers, potato chips, and other highly processed snacks contain this combination of fats and carbs.

Instead, combining carbs and fat with protein and fiber can help you feel full and may prevent overeating.

Summary: Your foods can impact your fat loss efforts. Consume nutrient-dense foods high in protein but limit foods that contain a combination of carbs and fats, as this combo makes it easier to overeat.

The best macronutrient ratio is the one you can stick to

While the macronutrient composition of your diet may not directly influence fat loss, it can affect your ability to adhere to a reduced-calorie diet.

This is important, as studies have shown that adherence to a reduced-calorie diet is the greatest predictor of weight loss.

However, sticking with a diet is difficult for most people, and it’s the reason why so many diets fail.

Individualize your macronutrient ratio based on your preferences and health to increase your chances of success on a reduced-calorie diet.

For example, people with type 2 diabetes may find it easier to control their blood sugars on a low-carb rather than a high-carb diet.

Conversely, otherwise healthy people may find they’re less hungry on a high-fat, low-carb diet, and it’s easier to follow than a low-fat, high-carb diet.

However, diets that emphasize a high intake of one macronutrient (like fats) and low intakes of another (like carbs) are not for everyone.

Instead, you may find that you can stick to a diet that balances macronutrients, which can also be effective for weight loss.

The acceptable macronutrient distribution ranges (AMDR) set forth by the Institute of Medicine of the National Academies recommend that people get the following:

In any case, choose the diet that best fits your lifestyle and preferences. This may take some trial and error.

Summary: Diets commonly fail because people can’t stick with them for long periods. Therefore, following a reduced-calorie diet that fits your preferences, lifestyle, and goals is important.


Macronutrients refer to carbs, fats, and protein — the three basic components of every diet.

Suggested read: High protein, low carb diet: A complete guide

Your macronutrient ratio doesn’t directly influence weight loss.

The acceptable macronutrient distribution ranges (AMDR) are 45–65% of your daily calories from carbs, 20–35% from fats, and 10–35% from protein.

To lose weight, find a ratio you can stick with, focus on healthy foods and eat fewer calories than you burn.

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